Low-grade inflammation: in close-up

Posted in Food Bites |
Key Facts: 
  • In LGI conditions, multiple triggers stimulate cytokine activity and C-reactive proteinon a mass scale

  • Triggers include fat tissue, fructose and leaky gut, leading to loss of 'immune tolerance'

  • Gluten and other nutrients damage the oral and gut barriers, setting off allergic reactions

  • Simple changes in diet and lifestyle can prevent breaches and heal the gut lining


Now we've lifted the lid on toxic food compounds – or 'anti-nutrients' – in various articles in Food Bites, let’s take a detailed look at what actually happens once the immune system revs up for action.

We know in response to acute infection or trauma our immune systems release an army of white cells, known as pro-inflammatory cytokines, together with a barrage of cytokine inhibitors (TNF-a, IL-1b, IL-6, IL-1, receptor agonist IL-1ra, soluble TNF-a-receptors sTNF-R and IL-10). We also know the transcription factor nuclear factor kappa B (NFkB) is behind this mass cytokine release that floods the whole body (systemic inflammation) with the intent to cause collateral damage and engulf 'invaders'.

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